Eleutherine plicata - Plants of the World Online | Kew Science

Toxicity evaluation of Eleutherine plicata Herb. extracts and possible ...

Eleutherine plicata Herb. is a plant of the Eleutherine genus, belonging to the Iridaceae family and widely distributed in Brazil. This plant is a bulbous herbaceous plant with an approximate size of 20-30 cm in height, with simple entire leaves, longitudinally pleated and inflorescence in pink flower panicles.

Frontiers | Anti-leishmanial activity of Eleutherine plicata Herb. and ...

Eleutherine plicata Herb. is widely used in Amazonian folk medicine for the treatment of amoebiasis, liver diseases, parasitic infections, hemorrhages, anemia (Couto et al., 2016), as well as for the healing of superficial wounds and gastric ulcers (Villegas et al., 1997).

Evaluation of the genotoxicity and mutagenicity of ... - ScienceDirect

The biological activities of Eleutherine plicata Herb. have been linked to isoeleutherin and eleutherin naphthoquinones. However, there are few reports in the literature regarding the cytotoxic and genotoxic potential of these compounds. There are reports in the literature that the inhibition of topoisomerase II (TOPO II) is involved in the ...

Anti-leishmanial activity of Eleutherine plicata Herb. and predictions ...

This study assessed the in vitro anti-leishmanial potential of the extract, fractions, and isoeleutherin from Eleutherine plicata, as well as the in silico interactions of isoeleutherin and its analogs with Trypanothione Reductase (TR), in addition to predicting pharmacokinetic parameters.

Eleutherine Plicata - Quinones and Antioxidant Activity | IntechOpen

Figure 1. Eleutherine plicata Herb. (herbaceousborneo.blogspot.com) The ethnoguided surveys conducted by Barbosa et al. (2009) [] in the city of Igarapé-Miri and by Jardim et al. [] in Santa Barbara, both in the Brazilian State Pará, revealed the use of Marupazinho (Eleutherine plicata Herb.) to treat diarrhea caused by amoeba and that the people prepare a tea from the bulb of the plant ...

In Vitro Cytotoxic Effects and Mechanisms of Action of Eleutherine ...

Previous studies have demonstrated the anti-glioma activity of Eleutherine plicata, which is related to three main naphthoquinone compounds-eleutherine, isoeleutherine, and eleutherol-but their mechanism of action remains elusive. Thus, the aim of this study was to investigate the mechanism of action of eleutherine on rat C6 glioma.

Genus Eleutherine: A review of its distribution, traditional uses ...

Eleutherine is a genus of bulbous, perennial and herbaceous plant in the Iridaceae family which have a wide range of biological activity. For instance, Eleutherine palmifolia (L.) Merr. (Dayak onion or bawang Dayak) is a plant that is widely used as an alternative medicine by people in Kalimantan.

In Vitro Cytotoxic Effects and Mechanisms of Action of Eleutherine ...

For the preparation of extracts, Eleutherine plicata of an average size of 5 cm were ground in a blender with 2 mL of distillated water and subjected to decoction for 2 min, under agitation, according to Baliza et al. (2022) . The mixture was distributed in extraction funnels, and hexane was added to the desired final volume.

Anti-leishmanial activity of Eleutherine plicata Herb. and predictions ...

fractions, and isoeleutherin from Eleutherine plicata, as well as the in silico interactions of isoeleutherin and its analogs with Trypanothione Reductase (TR), in addition to predicting pharmacokinetic parameters. Methods: From the ethanolic extract of E. plicata (EEEp) the dichloromethane fraction (FDEp) was obtained, and isoeleutherin isolated.

Naphthoquinones isolated from Eleutherine plicata herb: in vitro ...

Plasmodium falciparum is the cause of malaria and has become resistant to the drugs used to treat the disease. Therefore, the development for novel compounds with antimalarial activity has become urgent. Plant species, such as naphthoquinone-rich Eleutherine plicata, may provide novel substances that exhibit antimalarial activity and serve as an alternative for the treatment of this disease ...

Toxicity evaluation of Eleutherine plicata Herb. extracts and possible ...

Ethanol extract of Eleutherine plicata showed low in vitro and in vivo cytotoxic potential. The dichloromethane fraction was cytotoxic to HepG2 and caused DNA. However, no toxicity was observed in vivo. Isoeleutherin caused DNA damage by the comet method and activated caspase-8 in the in silico study.

In Vitro Cytotoxic Effects and Mechanisms of Action of Eleutherine ...

Previous studies have demonstrated the anti-glioma activity of Eleutherine plicata, which is related to three main naphthoquinone compounds—eleutherine, isoeleutherine, and eleutherol—but their mechanism of action remains elusive. Thus, the aim of this study was to investigate the mechanism of action of eleutherine on rat C6 glioma.

Eleutherine - Wikipedia

Eleutherine plicata. Herb. Synonyms; Galatea Salisb. 1812; Galatea Herb. 1819 name published without description; ... Eleutherine is a genus of herbaceous, perennial and bulbous plants in the family Iridaceae, first described as a genus in 1843. It is native to Latin America and the West Indies.

PDF Naphthoquinones isolated from Eleutherine plicata herb: in vitro ...

Eleutherine plicata, may provide novel substances that exhibit antimalarial activity and serve as an alternative for the treatment of this disease. From this plant species, ethanol extracts were obtained, fractionated, and the isolated substances eleutherin, and isoleutherin were characterized by nuclear magnetic resonance.

Total phenolic, flavonoid content, and antioxidant activity of bulbs ...

1. INTRODUCTION. Eleutherine(E.) bulbosa (Mill.) Urb belongs to the Iredaceae Eleutherine.Eleutherine bulbosa was also reported in the literature as Eleutherine plicata (Goldblatt & Snow, 1991).The research suggested that the plant of Iredaceae Elertherine included four species, namely E. bulbosa, E. latifolia, E. angusta, and E. citriodora (Xu, He, Zeng, Zhang, & Wang, 2012).

Toxicity evaluation of Eleutherine plicata Herb. extracts and possible ...

Eleutherine plicata Herb. is a plant of the Eleutherine genus, belonging to the Iridaceae family and widely distributed in Brazil. This plant is a bulbous herbaceous plant with an approximate size of 20-30 cm in height, with simple entire leaves, longitudinally pleated and inflorescence in pink flower panicles. They also have styloid crystals ...

Molecules | Free Full-Text | Participation of Oxidative Stress in the ...

From Eleutherine plicata, naphthoquinones, isoeleutherine, and eleutherol were isolated, and previous studies have reported the antioxidant activity of these metabolites. The present work evaluated the role of oxidative changes in mice infected with Plasmodium berghei and treated with E. plicata extract, fraction, and isolated compounds, as well as to verify possible oxidative changes induced ...

PDF Participation of Oxidative Stress in the Activity of Compounds Isolated ...

Keywords: Eleutherine plicata; isoeleutherine; eleutherine; eleutherol; oxidative stress 1. Introduction Malaria is one of the most serious infectious diseases, affecting low- and middle-income countries, where pregnant women and children under five years of age are among the population at risk.

Eleutherine bulbosa (Mill.) Urb. Bulb: Review of the Pharmacological ...

2. Morphological Characteristics. The Eleutherine genus is described as an herbaceous, rhizomatous, and perennial flowering plant with a predominantly red and wine bulb color similar to red onion (Figure 1), approximately around 20 to 30 cm [4,5].They have whole leaves, pleated at an average length of 25 cm, with a large panicle of white or pink flowers arranged at the apex of a long, dense ...