Sildenafil - Wikipedia

Sildenafil - StatPearls - NCBI Bookshelf

Sildenafil is a medication used in the management and treatment of erectile dysfunction and pulmonary arterial hypertension. It is in the phosphodiesterase-5 inhibitor (PDE5-I) class of medications. This activity describes the indications, actions, adverse effects, and contraindications of sildenafil as an agent in the clinical setting. Knowledge therein is critical for appropriate healthcare ...

How Viagra Helps Erectile Dysfunction: Sildenafil Mechanism of Action

Viagra mechanism of action. Sildenafil acts through a complex series of chemical reactions in order to relax smooth muscle tissue and allow for unimpeded blood flow within the penis. This process is enabled by the structural similarities between sildenafil and cGMP, which enables Viagra to act as a competitive binding agent of PDE-5. ...

Sildenafil: Dosage, Mechanism/Onset of Action, Half-Life - Medicine.com

Sildenafil is a phosphodiesterase type 5 (PDE-5) inhibitor that enhances the effect of nitric oxide on erectile dysfunction and pulmonary arterial hypertension. Learn about its dosage forms, pharmacokinetics, contraindications, and adverse reactions.

Sildenafil: from angina to erectile dysfunction to pulmonary ...

Abstract. In less than 20 years, the first selective type 5 phosphodiesterase inhibitor, sildenafil, has evolved from a potential anti-angina drug to an on-demand oral treatment for erectile dysfunction (Viagra), and more recently to a new orally active treatment for pulmonary hypertension (Revatio). Here we describe the key milestones in the ...

Sildenafil-oral Medication for Erectile Dysfunction-a Review

Mechanism of Action. Normal penile erection depends on the relaxation of smooth muscle in the corpora cavernosa. ... After perusing all the studies, the drug was launched in US as Viagra in 25, 50 and 100 mg tablets, after approval by FDA on 27 March 1998 for patients with erectile dysfunction. This was followed by advertising blitzkrieg by the ...

Sildenafil: efficacy, safety, tolerability and mechanism of action in ...

Sildenafil citrate is marketed under the trademark name Viagra and is widely used to treat male erectile dysfunction; therapeutic uses of this medication for other diseases related to vascular dysfunction are emerging. ... safety, tolerability and mechanism of action in treating erectile dysfunction Expert Opin Drug Metab Toxicol. 2005 Aug;1(2 ...

Viagra (Sildenafil Citrate): Side Effects, Uses, Dosage ... - RxList

Viagra is a prescription medicine used to treat the symptoms of erectile dysfunction. Learning about dosages, side effects, drug interactions, warnings, and more. Drugs & Vitamins. ... The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) ...

How Does Viagra® Work? - REX MD

Viagra's Mechanism. You achieve an erection through increased blood flow to spongey structures in your penis that fill with blood, called the coprus cavernosum. During arousal, the body signals for an erection through the release of nitric oxide in the penis and corpus cavernosum. Nitric oxide is the beginning of a signalling cascade that ...

Viagra: Package Insert / Prescribing Information - Drugs.com

VIAGRA is supplied as blue, film-coated, rounded-diamond-shaped tablets containing sildenafil citrate equivalent to 25 mg, 50 mg, or 100 mg of sildenafil. Tablets are debossed with PFIZER on one side and VGR25, VGR50 or VGR100 on the other to indicate the dosage strengths. 4. Contraindications.

Viagra Oral Tablet: How it Works, How Long it Lasts, Cost, and More

Learn about uses, how it works, and more for Viagra (sildenafil). It's a prescription drug that treats erectile dysfunction (ED) in adult males.

Sildenafil: from angina to erectile dysfunction to pulmonary ... - Nature

Registration and marketing of Viagra for ED. By 1997 more than 4,500 subjects had been exposed to sildenafil, and 21 separate clinical trials had demonstrated the efficacy of sildenafil in various ...

Sildenafil | C22H30N6O4S | CID 135398744 - PubChem

It has a role as a vasodilator agent and an EC 3.1.4.35 (3',5'- cyclic-GMP phosphodiesterase) inhibitor. It is a pyrazolopyrimidine, a member of piperazines and a sulfonamide. ChEBI. In eliciting its mechanism of action, sildenafil ultimately prevents or minimizes the breakdown of cyclic guanosine monophosphate ( cGMP) by inhibiting cGMP ...

Sildenafil: MedlinePlus Drug Information

Sildenafil (Viagra) is used to treat erectile dysfunction (impotence; inability to get or keep an erection) in men. Sildenafil (Liqrev, Revatio) is used to improve the ability to exercise in adults (Liqrev, Revatio) and children 1 year of age and older (Revatio) with pulmonary arterial hypertension (PAH; high blood pressure in the vessels carrying blood to the lungs, causing shortness of ...

Sildenafil: from the bench to the bedside - PMC - National Center for ...

Sildenafil is a PDE inhibitor. PDE inhibitors are not new to clinical practice. Nonspecific PDE inhibitors, such as theophylline and papaverine, cause smooth muscle relaxation by increasing levels of both cAMP and cGMP. However, the availability of subtype-specific PDE inhibitors is a recent advance.

Molecular mechanisms of the effects of sildenafil (VIAGRA)

The molecular mechanisms of the effects of sildenafil, a specific inhibitor of cyclic guanosine monophosphate (cGMP) phosphodiesterases are briefly reviewed. The second messenger cGMP as well as its molecular targets (with the exception of the photoreceptor signal transduction machinery) have long played an underdog role compared with cyclic ...

Viagra (sildenafil): Side effects, dosage, how long it lasts, and more

Viagra (sildenafil) is a brand-name prescription drug that's used to treat erectile dysfunction (ED). Learn about side effects, warnings, dosage, and more.

Erectile dysfunction: Viagra and other oral medications

Sildenafil (Viagra). This medicine works best when you take it on an empty stomach an hour before sex. The body takes longer to absorb it after a high-fat meal or alcohol. Its effects often last for 4 to 5 hours. It might work longer if you have mild to moderate erectile dysfunction. Vardenafil.

Molecular mechanisms of the effects of sildenafil (VIAGRA®)

Abstract. The molecular mechanisms of the effects of sildenafil, a specific inhibitor of cyclic guanosine monophosphate (cGMP) phosphodiesterases are briefly reviewed. The second messenger cGMP as well as its molecular targets (with the exception of the photoreceptor signal transduction machinery) have long played an underdog role compared with ...

Effects of Sildenafil Citrate (Viagra) Combined With Nitrate on the ...

Sildenafil citrate (Viagra) is a selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5) and is indicated for the treatment of erectile dysfunction. 1 The physiological mechanism responsible for erection of the penis involves the release of NO in the corpus cavernosum in response to sexual stimulation. NO activates the enzyme guanylate cyclase, which results in locally increased ...

Effects and mechanisms of action of sildenafil citrate in human ...

The effects of sildenafil citrate on the pulmonary vasculature and on pulmonary artery pressure are increasingly well understood. Sildenafil citrate acts by reducing cGMP breakdown, making pulmonary vascular smooth muscle more sensitive to both endogenous and exogenous NO, reducing ventilation/perfusion mismatch and hypoxia [ 1, 9, 10 ...

Use of Sildenafil (Viagra) in Patients With Cardiovascular Disease

A. Sildenafil (Viagra) Use for Erectile Dysfunction. Male erectile dysfunction defined as "the inability to attain and/or maintain penile erection sufficient for satisfactory sexual performance" 1 is a common problem in the United States affecting between 10 and 30 million men. 2 3 Sexual dysfunction in men after the diagnosis of coronary artery disease or a myocardial infarction is common.

Visual Side Effects Linked to Sildenafil Consumption: An Update

Cytotoxicity mechanisms of cyclic guanosine monophosphate (cGMP) in photoreceptors. The loss of phosphodiesterase (PDE6) function, or the prolonged activation of retinal guanylyl cyclase (GC) due to dominant mutations in the guanylyl cyclase-activating proteins (GCAPs), leads to an increase in the concentration of cytosolic cGMP which, in turn, causes continuous stimulation of the of protein ...